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KLOW Meds

Repair findings, tested again.

KLOW Meds reading list

The experiments reward a closer look than the blend’s tidy name suggests. Here are the sources, including the reviews that collect much of the earlier work.

Starting with replication

The orthopaedic systematic review is the starting point for the question running through this site. For the experimental details, the rat tendon work, VEGFR2 study and isolated aortic-ring experiments address distinct mechanical and vascular questions.

I would open a primary study before drawing a conclusion from a review’s list of possible applications. The route, tissue and comparison can change the meaning of an otherwise familiar ingredient name.

  1. Krivic A, Anic T, Seiwerth S, Huljev D, Sikiric P. Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation. Journal of Orthopaedic Research. 2006. ↗
  2. Hsieh MJ, et al. Therapeutic potential of pro-angiogenic BPC 157 is associated with VEGFR2 activation and up-regulation. Journal of Molecular Medicine. 2017. ↗
  3. Hsieh MJ, et al. Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Scientific Reports. 2020. ↗
  4. Staresinic M, Petrovic I, Novinscak T, et al. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Journal of Orthopaedic Research. 2003. ↗
  5. Sikiric P, et al. Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Current Pharmaceutical Design. 2006. ↗
  6. Pickart L, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015. ↗
  7. Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxidative Medicine and Cellular Longevity. 2012. ↗
  8. Campbell JD, Spira A, et al.; discussed in Pickart 2018 review. Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. Cosmetics / PLoS ONE. 2012. ↗
  9. Awa T, Nogami M, Otomo S. Effects of copper tripeptide on the growth and biochemistry of cultured human dermal papilla cells. International Journal of Cosmetic Science. 1995. ↗
  10. Kleinman HK, Sosne G. The regenerative peptide thymosin beta4 accelerates the rate of dermal healing in preclinical animal models and in patients. Annals of the New York Academy of Sciences. 2012. ↗
  11. Ehrlich HP, Hazard SW 3rd. Thymosin beta4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts. Annals of the New York Academy of Sciences. 2010. ↗
  12. Ruff D, Crockford D, Girardi G, Zhang Y. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Annals of the New York Academy of Sciences. 2010. ↗
  13. Sosne G, Dunn SP, Kim C, et al. 0.1% RGN-259 (Thymosin beta 4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial. International Journal of Molecular Sciences. 2022. ↗
  14. Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008. ↗
  15. Viennois E, Pujada A, Zen J, Merlin D. Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model. Cellular and Molecular Gastroenterology and Hepatology. 2016. ↗
  16. Brzoska T, Luger TA, Maaser C, Abels C, Bohm M. Alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Annals of Rheumatic Diseases. 2003. ↗
  17. Sikiric P, et al. Stable Gastric Pentadecapeptide BPC 157 May Recover Brain-Gut Axis and Gut-Brain Axis Function. Pharmaceuticals (Basel). 2023. ↗
  18. Wang H, et al. Recombinant human thymosin beta 4 improves ischemic cardiac dysfunction in mice and patients with acute ST-segment elevation myocardial infarction after reperfusion. Cardiovascular Research. 2025. ↗
  19. Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM. Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review. HSS Journal. 2025. ↗
  20. Jozwiak M, et al. Multifunctionality and Possible Medical Application of the BPC 157 Peptide - Literature and Patent Review. Pharmaceuticals (Basel). 2025. ↗
  21. Multiple authors. BPC-157 and GHK-Cu in Wound Healing and Tissue Repair: A Review of Clinical Efficacy and Safety. ResearchGate preprint. 2025. ↗
  22. Multiple authors. Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review. International Journal of Medical Sciences. 2025. ↗
  23. Sikiric P, et al. Stable Gastric Pentadecapeptide BPC 157 as a Therapy for the Disabled Myotendinous Junctions in Rats. Biomedicines. 2021. ↗
  24. Mendias CL, Awan TM. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. Sports Medicine. 2026. ↗
  25. Malinda KM, et al. Thymosin beta4 accelerates wound healing. Journal of Investigative Dermatology. 1999. ↗
  26. Wang Y, et al. Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. Frontiers in Pharmacology. 2022. ↗
  27. Hostynek JJ, Dreher F, Maibach HI. Human skin penetration of a copper tripeptide in vitro as a function of skin layer. Inflammation Research. 2011. ↗